Mitochondrial dysfunction in cumulus-oocyte complexes increases cell-free mitochondrial DNA
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چکیده
منابع مشابه
1 mitochondrial DNA dysfunction by PAHs Mitochondrial
Background: Increased mitochondrial DNA copy number (mtDNAcn) is a biological response to mtDNA damage and dysfunction predictive of lung cancer risk. Polycyclic aromatic hydrocarbons (PAHs) are established lung carcinogens and may cause mitochondrial toxicity. Whether PAH exposure and PAHrelated nuclear DNA (nDNA) genotoxic effects are linked with increased mtDNAcn has never been evaluated. Me...
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In 1979, it was observed that parkinsonism could be induced by a toxin inhibiting mitochondrial respiratory complex I. This initiated the long-standing hypothesis that mitochondrial dysfunction may play a key role in the pathogenesis of Parkinson's disease (PD). This hypothesis evolved, with accumulating evidence pointing to complex I dysfunction, which could be caused by environmental or genet...
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ژورنال
عنوان ژورنال: Journal of Reproduction and Development
سال: 2018
ISSN: 0916-8818,1348-4400
DOI: 10.1262/jrd.2018-012